Оценка местного и гуморального иммунитета у больных с хроническим пиелонефритом
Аннотация
Дана характеристика взаимосвязи между заболеванием хронического пиелонефрита и
состоянием ротовой жидкости путем исследования изменений уровня провоспалительных и противовоспалительных цитокинов в различных биологических жидкостях организма, для включения в последующем дифференцированной иммунокоррекции сочетанной формы заболевания. Обследованы 68 больных с хроническим пиелонефритом в возрасте от 25 до 65 лет и старше, с длительностью заболевания от 3-х до 10 лет (из них 67,2 % женщины и 32, 8 % — мужчин). Выявлено, что повышенное содержание провоспалительных медиаторов ИЛ-1, ИЛ-6, ИЛ-8 и ФНО-α в ротовой жидкости у больных с ХП могут активировать воспалительно-деструктивные процессы и проявляться в виде обострений заболеваний пародонта и СОПР.
The article describes the relationship between the disease of chronic pyelonephritis and the state of the oral fluid by studying the changes in the level of pro-inflammatory and anti-inflammatory cytokines in various biological fluids of the body, in order to include in the subsequent differentiated immunocorrection of the combined form of the disease. We examined 68 patients with chronic pyelonephritis aged 25 to 65 years and older, with a disease duration of 3 to 10 years (of which 67.2% were women and 32.8% were men). It was revealed that the increased content of pro-inflammatory mediators IL-1, IL-6, IL-8 and TNF-α in the oral fluid of patients with CP can activate inflammatory and destructive processes and manifest themselves in the form of exacerbations of periodontal disease and oral mucosa.
The article describes the relationship between the disease of chronic pyelonephritis and the state of the oral fluid by studying the changes in the level of pro-inflammatory and anti-inflammatory cytokines in various biological fluids of the body, in order to include in the subsequent differentiated immunocorrection of the combined form of the disease. We examined 68 patients with chronic pyelonephritis aged 25 to 65 years and older, with a disease duration of 3 to 10 years (of which 67.2% were women and 32.8% were men). It was revealed that the increased content of pro-inflammatory mediators IL-1, IL-6, IL-8 and TNF-α in the oral fluid of patients with CP can activate inflammatory and destructive processes and manifest themselves in the form of exacerbations of periodontal disease and oral mucosa.