Экспериментальные модели для изучения перитонита

  • № 1 2018

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32

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35

Язык: русский

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Аннотация

Знание роли патогенов и эндотоксинов при перитоните и его осложнениях может повысить точность диагностики и улучшить результаты лечения. Этиология перитонита – многофакторна. Заболевание затрагивает сердечно-сосудистую, иммунную, эндокринную системы организма человека. Модели перитонита у животных помогают оценить эффективность и безопасность потенциальных терапевтических агентов. Однако их физиологические ограничения служат барьером для перевода результатов исследования в клиническую практику. Информация на основе фактических данных могла бы потенциально способствовать интерпретации результатов исследований на животных, которые могут с успехом использоваться в клинических испытаниях.

Перитонитдаги патогенлар ва эндотоксинларнинг ролини билиш касаллик диагностикаси ва даво натижаларини самарадорлигини янада оширади. Перитонит этиологияси кўп факторли бўлиб юрак қон-томир, иммун ва эндокрин фаолиятларини издан чиқаради. Касалликни даволашда ҳар-хил терапевтик агентлар уларнинг таъсир механизмлари, уларнинг зарари ва самарадорлигини баҳолаш учун перитонитнинг ҳайвон моделлари энг қулай ва хафсиз усул, аммо уларнинг физологик чегаралари тадқиқот натижаларини амалда клиникага тадбиқ этишга тўсқинлик қилади. Моделларни аниқ саралаб олиш касалликни ҳар-хил аспектларини ўрганишда катта ёрдам беради. Далилларга асосланган маълумотлар ҳайвонларнинг тадқиқот натижаларини клиник шароитларда муваффақиятли ишлатиши мумкин бўлган изоҳлашни осонлаштириши мумкин.

Knowledge of the role of pathogens and endotoxins in peritonitis and its complications can improve diagnostic accuracy and improve treatment outcomes. The etiology of peritonitis is multifactorial. The disease affects the cardiovascular, immune, endocrine systems of the human body. Models of peritonitis in animals help to evaluate the efficacy and safety of potential therapeutic agents. However, their physiological limitations serve as a barrier to translating research results into clinical practice. Evidence-based information could potentially facilitate the interpretation of animal research results that can be successfully used in clinical trials.

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