Bioavailability of fluoride from 3 different toothpastes in vivo

  • № 4(69) 2017

Страницы: 

20

 – 

22

Язык: английский

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Аннотация

The aim of the present 3-leg crossover study was to assess the oral bioavailability of fluoride delivered with two NaF toothpastes (one longer marketed 1350 ppm and one recently introduced 1450ppm F), and a MFP toothpaste (1450 ppm F). Ten adult volunteers brushed their teeth for 1 min, followed by rinsing with 10 ml de-ionised purified water for 10 s. Samples of about 2mL of whole mixed unstimulated saliva were collected 1, 5, 10, 20, 30, 60, 180 min after brushing. Individual salivary fluoride-time plots were established and the area under the curve (AUC) calculated. Cmax and AUC of MFP were significantly (p0.05). The newly introduced NaF toothpaste had a sufficient bioavailability of fluoride comparable to that of standard NaF toothpaste. The MFP toothpaste showed a lower availability of ionisable fluoride.

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